Cure Me cures the caster of poison. However, unlike antipoisons, this spell does not make you immune to poison for a short amount of time. This means that if you are fighting a monster that can poison, you will most likely be poisoned again straight after casting the spell. This spell is useful in one-off poison places such as the poison Trip Wire trap in Isafdar. The spell will also convert venom to poison. As with all Lunar spells, the quest Lunar Diplomacy must be completed to cast this spell.
This can also be useful in minigames such as Pyramid Plunder to avoid needing anti-poison potions. As runes are stackable and potions are not, using the cure me spell can mean staying there for longer. However this is not generally used due to the fact that there is an altar in Sophanem and players can use the free prayer book to cure themselves (although to acquire this book the quest The Great Brain Robbery must be completed at least up until the point where players must travel to the Monastery).
Ironmen may opt to use Cure Me as a lesser alternative to anti-venom while fighting Zulrah if they do not have 87 Herblore.