Essence could refer to:
- Rune essence, mined at the rune essence mine at below level 30 Mining.
- Pure essence, mined at the rune essence mine at level 30 Mining or above.
- The Rune Essence Mine, accessible after the Rune Mysteries quest.
- Essence impling, an impling caught with at least level 42 in Hunter.
- Essence impling jar, the lootable item obtained as a result of catching an essence impling.
- Magic essence, a potion that can be made during and after Fairy Tale II - Cure a Queen.
- Daeyalt essence, created by trading in daeyalt shards mined at the Daeyalt Essence Mine.
- The Daeyalt Essence Mine, accessible after the Sins of the Father quest.