The Misthalin–Morytania War was a conflict between the vampyres of Morytania and the Varrockian army. After taking over all of Hallowvale in the Third Age, Lord Drakan wanted to expand his borders, so he crossed the River Salve and waged war on the Kingdom of Misthalin. After months of war against the humans, the vampyres retreated back to Morytania, and that led to the blessing of the River Salve to keep them there. Of those priestly warriors, Ivandis Seergaze still tried to battle the vampyres, which ultimately lead to his death.
Though the Warriors kept back the tide, the vampyres had soon recovered from their losses and grew ever stronger, cracking down harder on the struggling humans of the land, and thus ensued the Sanguinesti Liberation War, as the Myreque tried to claim back the Sanguinesti region of Morytania from the control of the merciless House Drakan.