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Parasites are thrown at players by The Nightmare while fighting her. After the Parasite has grown, it will burst out of the player, damaging them and proceeding to heal The Nightmare until killed. Sanfew serum and Relicym's balm will weaken the parasite.

If you don't weaken the parasite inside you, that damage that is dealt will be added onto the parasites overall health once burst out of you.